Ok so after submitting this to bugs, I was instructed to post here so I hope someone can help with this issue. Searching the forums I found one reference to the same issue but did not see a resolution.
The following is the information that I submitted
Windows Server 2012 R2 running IIS
SugarCRM CE 6.5.22
SuiteCRM 7.5.1 by way of Migration using the Upgrade path.
Although this message appears to be random I have noticed that they show up almost every time I create and new entry in a module and I click on save. It is also important to note that if I hit F5 when I get this error message “No valid themes are found on this instance” the page appears with not problems.