Email can't send from user but in admin it's work

Importantly, will it overwrite my custom fields and form layout changes?

If you’re not comfortable adding code then certainly yes, the upgrade through the User Interface is the way to go.

https://docs.suitecrm.com/admin/installation-guide/using-the-upgrade-wizard/

If your customizations are upgrade-safe, then the upgrade won’t break them.

I suppose you did all your customizations through the UI (Studio, Dropdown editor, Module Builder) so they should all be upgrade-safe.

However, you need to understand that upgrades always carry some risk and proper backups should be made prior to the upgrade (code + database).

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